Dynamic Hubs Show Competitive and Static Hubs Non-Competitive Regulation of Their Interaction Partners
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چکیده
منابع مشابه
Dynamic Hubs Show Competitive and Static Hubs Non-Competitive Regulation of Their Interaction Partners
Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the 1 or 2 interface hubs of Saccharomyce...
متن کاملTheory and Methodology Location of hubs in a competitive environment
We oer a formulation that locates hubs on a network in a competitive environment; that is, customer capture is sought, which happens whenever the location of a new hub results in a reduction of the current cost (time, distance) needed by the trac that goes from the speci®ed origin to the speci®ed destination. The formulation presented here reduces the number of variables and constraints as co...
متن کاملLocation of Hubs in a Competitive Environment 1
We o er a formulation that locates hubs on a network in a competitive environment; that is, customer capture is sought, which happens whenever the location of a new hub results in a reduction of the current cost (time, distance) needed by the tra c that goes from the speci ed origin to the speci ed destination. The formulation presented here reduces the number of variables and constraints as co...
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This article explores the development of previous models to determine hubs in a competitive environment. In this paper, by comparing parameters of the ticket price, travel time and the service quality of hub airports, airline hubs are divided into six categories. The degree of importance of travel time and travel cost are determined by a multivariate Lagrange interpolation method, which can pla...
متن کاملIdentifying Hubs in Protein Interaction Networks
BACKGROUND In spite of the scale-free degree distribution that characterizes most protein interaction networks (PINs), it is common to define an ad hoc degree scale that defines "hub" proteins having special topological and functional significance. This raises the concern that some conclusions on the functional significance of proteins based on network properties may not be robust. METHODOLOG...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0048209